 Variations on CORRECT RIDGES |
 Variations on INCORRECT RIDGES |
 Although rare, there are purebred Rhodesian Rdigebacks who are born without a ridge. (Most breeders call them "ridgeless Ridgebacks. I prefer the term a friend of mine used when I referred to his puppy as a ridgeless...... He said " I have you know that MY dog is not a ridgeless Ridgeback, it's a South African Lion Hound! " LOL!) Serving as the lovely models are (L) Jade and (R) Henna Moon, both proud owners of Liz Druitt. (Actually, they were modeling their spiffy new collars in my front yard) |
Nature Genetics 39, 1318 - 1320 (2007)
Published online: 30 September 2007 | doi:10.1038/ng.2007.4
Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs
Nicolette H C Salmon Hillbertz1, Magnus Isaksson2, Elinor K Karlsson3,4, Eva Hellmén2,5, Gerli Rosengren Pielberg6, Peter Savolainen7, Claire M Wade3,8, Henrik von Euler9, Ulla Gustafson1, Åke Hedhammar9, Mats Nilsson2, Kerstin Lindblad-Toh3,6, Leif Andersson1,6 & Göran Andersson1
The
dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a
dominant mutation that also predisposes to the congenital developmental
disorder dermoid sinus. Here we show that the causative mutation is a
133-kb duplication involving three fibroblast growth factor (FGF)
genes. FGFs play a crucial role in development, suggesting that the
ridge and dermoid sinus are caused by dysregulation of one or more of
the three FGF genes during development.
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